Endocrine Abstracts

Glucocorticoid-induced osteoporosis is the most common form of secondary osteoporosis. Glucocorticoid is known to cause hyperparathyroidism due to parathyroid hormone (PTH) secretion. In addition, glucocorticoid and PTH have also been reported to induce RANKL mRNA expression in osteoblasts and promote osteoclastogenesis. However, little is known about cooperative effects of these hormones. The purpose of this study was to clarify the regulation of RANKL mRNA expression by gluc...